An overview of the immunology of aids

Testing regularly for HIV means you can get antiretroviral treatment if you need it and stay healthy.

An overview of the immunology of aids

Immunology[ edit ] After the virus enters the body there is a period rapid viral replicationleading to an abundance of virus in the peripheral blood. During primary infection, the level of HIV may reach several million virus particles per milliliter of blood.

A vigorous immune response eventually controls the infection and initiates the clinically latent phase. Continuous HIV replication results in a state of generalized immune activation persisting throughout the chronic phase.

The activation and proliferation of T cells that results from immune activation provides fresh targets for HIV infection. Although new T cells are continuously produced by the thymus to replace the ones lost, the regenerative capacity of the thymus is slowly destroyed by direct infection of its thymocytes by HIV.

CD4 T-cell Death and Inflammation[ edit ] Recent studies employed an ex vivo human lymphoid aggregate culture HLAC system formed with fresh human tonsil or spleen tissue [8] to model molecular and cellular events in human tissues during in vivo HIV infection.

This viral DNA is sensed by gamma-interferon-inducible protein 16 IFI16[11] which produces an innate immune response against the virus by activating caspase 1 in IFI16 inflammasomes and inducing pyroptosisa highly inflammatory form of programmed cell death.

Rather than the virus playing a major role, it is the host response to viral DNA produced during abortive infection that triggers CD4 T-cell death.AIDS is a set of symptoms and illnesses that develop as a result of advanced HIV infection which has destroyed the immune system. Fewer people develop AIDS now because treatment for HIV means that more people are staying well.

Department of Pathology and Laboratory Medicine McGovern Medical School.

An overview of the immunology of aids

Toggle Immunology of AIDS. Inside Links for Lectures. Department of Pathology and Laboratory Medicine at McGovern Medical School.

The Immune System -- An Overview -

Search this department Submit. Medical School. HIV is a virus that lives in human blood, sexual fluids, and breast milk. It weakens your immune system, so your body has a hard time fighting off common germs, viruses, fungi, and other invaders. This article provides an overview and reviews the HIV pandemic, the basic biology and immunology of the virus (e.g., genetic diversity of HIV and the viral life cycle), the phases of disease progression, modes of HIV transmission, HIV testing, immune.

Most cytokines and substances from body fluids, such as saliva, tears and milk, are the components of innate immune system. Macrophages and dentritic cells bridge between the innate immunity and the acquired immunity. Jul 13,  · Watch video · The human immunodeficiency virus, or HIV, is a virus that attacks the immune system, specifically CD4 cells (or T cells).

The virus .

The science of HIV and AIDS - overview | AVERT